According to an accepted manuscript published in the American Journal of Roentgenology (AJR), upgrade and downgrade rates from targeted biopsy to radical prostatectomy were not significantly different between patients whose MRI examinations were clinically interpreted using PI-RADS Version v2.0 or v2.1.

“Implementation of the most recent PI-RADS update did not improve the incongruence in prostate cancer grade assessment between targeted biopsy and surgery,” writes corresponding author Baris Turkbey, MD, from the Molecular Imaging Branch of the National Cancer Institute at National Institutes of Health in Bethesda, Md.

Turkbey and his colleagues’ AJR study entailed a retrospective post-hoc analysis of patients who underwent 3-T prostate MRI at a single institution from May 2015 to March 2023 during prospective clinical trials. From trial participants, the authors identified those who underwent MRI followed by MRI/ultrasound-fusion guided targeted biopsy and radical prostatectomy within a one-year interval. A single genitourinary radiologist performed clinical interpretations of the MRI examinations using PI-RADS v2.0 from May 2015 to March 2019, and using PI-RADS v2.1 from April 2019 to March 2023.

Ultimately, patients who underwent MRI interpreted by PI-RADS v2.0 and PI-RADS v2.1 showed no significant differences in respective rates of upgrade (29% vs. 22%, p=0.15), downgrade (19% vs. 21%, p=0.76), clinically significant upgrade (14% vs. 10%, p=0.27), or clinically significant downgrade (1% vs. 1%, p>0.99) from targeted biopsy to radical prostatectomy grade group.

Featured image: Lesion (arrow) shows hypointensity on T2-weighted image (A), hyperintensity on high b-value DWI (B), hypointensity on ADC map (C), and focal early enhancement on dynamic contrast-enhanced image (D). Lesion assessed as category 4 using PI-RADS version 2.1 MRI-targeted biopsy of lesion revealed prostate adenocarcinoma with International Society of Urogenital Pathology (ISUP) grade group 2. At subsequent radical prostatectomy performed 6 months after biopsy, ISUP grade group upgraded to 3.