PSMA-targeted 18F-DCFPyL-PET/CT imaging demonstrated excellent diagnostic performance in men with biochemically relapsed prostate cancer in terms of a correct localization rate that far exceeded the criteria to meet the primary end point, according to findings from the phase 3 CONDOR trial, according to a study in Journal of Clinical Oncology and reported in Targeted Oncology.
“The CONDOR study met its primary endpoint. Indeed, it well exceeded it. And it demonstrated excellent diagnostic performance of PyL PET in men with biochemically relapsed prostate cancer, even at very low PSA values,” said Michael J. Morris, MD, when presenting findings during the 2020 ASCO Virtual Scientific Program. “It clearly showed superiority to the standard imaging these men received as part of their local work-ups.”The CONDOR trial is the second of 2 prospective, multicenter trials examining the diagnostic performance of 18F-DCFPyL-PET/CT. The first was the OSPREY trial, which examined the use of the PET tracer in patients with clinically localized disease preoperatively as well as in patients with locally recurrent or metastatic disease. This phase 2/3 study showed high specificity in detecting lymph node disease involvement and significant positive predictive value (PPV) in the detection of metastatic disease.
Read more from Targeted Oncology and find the study in Journal of Clinical Oncology.