A team led by researchers from Queen Mary University of London has developed a new artificial intelligence (AI) tool that is able to automatically measure the amount of fat around the heart from MRI scan images. The research is published in the journal Frontiers in Cardiovascular Medicine.
Using the new tool, the team was able to show that a larger amount of fat around the heart is associated with significantly greater odds of diabetes, independent of a person’s age, sex, and body mass index (BMI).
The distribution of fat in the body can influence a person’s risk of developing various diseases. The commonly used measure of BMI mostly reflects fat accumulation under the skin, rather than around the internal organs. Specifically, there are suggestions that fat accumulation around the heart may be a predictor of heart disease, and has been linked to a range of conditions, including atrial fibrillation, diabetes, and coronary artery disease.
Lead researcher Zahra Raisi-Estabragh, MBBS, PhD, from Queen Mary University of London says: “Unfortunately, manual measurement of the amount of fat around the heart is challenging and time-consuming. For this reason, to date, no one has been able to investigate this thoroughly in studies of large groups of people.”
“To address this problem, we’ve invented an AI tool that can be applied to standard heart MRI scans to obtain a measure of the fat around the heart automatically and quickly, in under three seconds,” Raisi-Estabragh adds. “This tool can be used by future researchers to discover more about the links between the fat around the heart and disease risk, but also potentially in the future, as part of a patient’s standard care in hospital.”
The research team tested the AI algorithm’s ability to interpret images from heart MRI scans of more than 45,000 people, including participants in the UK Biobank, a database of health information from more than 500,000 participants from across the UK. The team found that the AI tool was accurately able to determine the amount of fat around the heart in those images, and it was also able to calculate a patient’s risk of diabetes.
Steffen Petersen, MD, PhD, MSc, FSCMR, a professor at Queen Mary University of London, who supervised the project, says: “This novel tool has high utility for future research and, if clinical utility is demonstrated, may be applied in clinical practice to improve patient care. This work highlights the value of cross-disciplinary collaborations in medical research, particularly within cardiovascular imaging.”