Sending a “selfie” to the doctor could be a cheap and easy way to detect heart disease, according to the authors of a new study published in the European Heart Journal. The study is the first to show that it’s possible to use a deep learning computer algorithm to detect coronary artery disease (CAD) by analyzing four photographs of a person’s face.
Although the algorithm needs to be developed further and tested in larger groups of people from different ethnic backgrounds, the researchers say it has the potential to be used as a screening tool that could identify possible heart disease in people in the general population or in high-risk groups, who could be referred for further clinical investigations.
“To our knowledge, this is the first work demonstrating that artificial intelligence can be used to analyze faces to detect heart disease. It is a step toward the development of a deep learning-based tool that could be used to assess the risk of heart disease, either in outpatient clinics or by means of patients taking ‘selfies’ to perform their own screening. This could guide further diagnostic testing or a clinical visit,” says Zhe Zheng, who led the research and is vice director of the National Center for Cardiovascular Diseases and vice president of Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China.
He continues: “Our ultimate goal is to develop a self-reported application for high risk communities to assess heart disease risk in advance of visiting a clinic. This could be a cheap, simple and effective of identifying patients who need further investigation. However, the algorithm requires further refinement and external validation in other populations and ethnicities.”
It is known already that certain facial features are associated with an increased risk of heart disease. These include thinning or grey hair, wrinkles, ear lobe crease, xanthelasmata (small, yellow deposits of cholesterol underneath the skin, usually around the eyelids) and arcus corneae (fat and cholesterol deposits that appear as a hazy white, grey or blue opaque ring in the outer edges of the cornea). However, they are difficult for humans to use successfully to predict and quantify heart disease risk.
Zheng; Xiang-Yang Ji, director of the Brain and Cognition Institute in the Department of Automation at Tsinghua University, Beijing; and other colleagues enrolled 5,796 patients from eight hospitals in China to the study between July 2017 and March 2019. The patients were undergoing imaging procedures to investigate their blood vessels, such as coronary angiography or coronary computed tomography angiography (CCTA). They were divided randomly into training (5,216 patients, 90%) or validation (580, 10%) groups.
Trained research nurses took four facial photos with digital cameras: one frontal, two profiles and one view of the top of the head. They also interviewed the patients to collect data on socioeconomic status, lifestyle and medical history. Radiologists reviewed the patients’ angiograms and assessed the degree of heart disease depending on how many blood vessels were narrowed by 50% or more (≥ 50% stenosis), and their location. This information was used to create, train and validate the deep learning algorithm.