A study led by Canadian researchers provides empirical evidence that mindfulness has a significant impact on the brain of women suffering from neuropathic pain related to breast cancer treatment. The researchers showed that mindfulness-based stress reduction (MBSR) helps modulate neuropathic pain.

We talked to senior author Andra Smith, PhD, full professor at the University of Ottawa School of Psychology, to learn more about the most recent findings published in the journal Mindfulness.

Why Did You and Your Team Decide to Look at Mindfulness to Improve Pain-Related Problems?

“Neuropathic pain is a very common side effect of chemotherapy and other breast cancer treatments. Painkillers do not always work, and quality of life, cognitive abilities, and overall well-being can be reduced due to this pain. Due to these negative effects and the complexity of treatment for this type of pain following breast cancer treatment, it is important to provide adjunct treatment and management options.

We have heard a lot about mindfulness over the past few years, about how it helps people relax and feel better. If mindfulness, a non-pharmacological tool, can be used to help with neuropathic pain, women will feel better and might not experience such disruptive pain.

Pain is a subjective experience and mindfulness is often dismissed as a ‘buzzword.’ But our research provides objective, empirical evidence of a significant impact of mindfulness on the brain of these women.”

These images represent brain activity significantly reduced following the MBSR while the women were performing an Emotional Stroop task during fMRI

How Was the Research Conducted?

“We investigated the impact of an eight-week mindfulness-based stress reduction (MBSR) program on emotional reactivity among a sample of breast cancer survivors with chronic neuropathic pain. We used state-of-the-art brain imaging at The Ottawa Hospital, on their 3T MRI scanner and collected data on white matter health, brain activity during emotional pain related word processing and during resting state.

Women with neuropathic pain were imaged before and after an MBSR program, or treatment as usual. Pain, quality of life, and imaging were compared between the two groups and within the MBSR group pre- and post-MBSR.”

What Did You Find?

“We observed major reductions in brain activity following mindfulness-based stress reduction in regions related to pain, emotional regulation, and cognitive processing. Both pain severity and pain interference, for the MBSR group, were significantly reduced after the eight-week training.

Our results show a significant improvement in brain health as well as in pain perception. There are many anecdotal reports of how this or that made a person ‘feel better’ but the really exciting results here are that we can see that there are actual changes in the brain and the way a person can alter their response to pain.”

Why Is It Important?

“This research provides hope for a noninvasive method of easing the struggle of chronic neuropathic pain in women following breast cancer treatment. Pain is something that people fear, and many people run into significant secondary problems because of their pain medication use, including drug misuse and mental health issues. Mindfulness has a neurophysiological effect that can alter one’s perception of pain.

This research shows that there are adjunctive treatment options. If used properly, the information we have published can improve health outcomes for the people involved and could potentially also reduce health costs, as well as some of the related problems – particularly those related to mental health.”